Why does grapefruit turn one statin into several? In this video, we explain how intestinal CYP3A4 and furanocoumarins in grapefruit affect statin metabolism, and why the 1989 accident put a fruit on a drug label. You'll learn why some statins are heavily affected while others are not, and why this isn't an inconsistency. Chapters: 00:00 WHY DOES GRAPEFRUIT TURN ONE STATIN 00:12 Heavily Dependent 00:23 Moderate 00:43 Not Inconsistency